• br Results br Discussion HSPCs

  2018-10-22

  

  Results Discussion HSPCs include rapidly cycling progenitor cells that produce vast numbers of effector cells on a daily basis. It was therefore not unexpected to find that genes involved in PD 0325901 and metabolic growth were enriched in HSPCs, but surprisingly, we also discovered that many

• In addition to regulating the pluripotent state SOX

  2018-10-22

  

  In addition to regulating the pluripotent state, SOX2 controls the formation of several cell types during fetal development, such as the nervous system (Ellis et al., 2004), anterior foregut endoderm (Que et al., 2007), and sensory cells of the taste bud and inner ear (Dabdoub et al., 2008; Kiernan

• We also showed that the

  2018-10-22

  

  We also showed that the transient suppression of Nanog by siRNA annulled the self-renewal capacity and tumorigenic activity of GSCs and induced the differentiation of these cells. Recent evidence suggested a shared genomic fingerprint between ESCs, cancer cells, and cancer stem cells. Nanog, Sox2, a

• Biotin-tyramide br Conflict of interest The following are th

  2018-10-22

  

  Conflict of interest The following are the supplementary data related to this article. Acknowledgments This work was funded by Qatar Foundation NPRP Grant 08-663-3-140 and NPRP Grant 09-1099-3-279; Qatar Foundation UREP Grant 06-116-1-023; and a Qatar Foundation Qatar Technology Transfer Gran

• The ontological functional analysis of

  2018-10-20

  

  The ontological functional analysis of the INT proteins supported fate specificity in the INT mechanisms integrating the dofetilide and ESC differentiation. Furthermore, cellular processes which were not obviously related to either the cell cycle or to cell differentiation were highlighted. A notab

• These conclusions rest mainly on three experimental facts

  2018-10-20

  

  These conclusions rest mainly on three experimental facts: a model of myocardial injury with patent coronary circulation to test the spontaneous regenerative capacity of eCSCs; in situ labelling and genetic tracking the fate of c-kit positive cardiac stem BLU 9931 manufacturer and the replacement of

• Time lapse images were taken on an inverted Zeiss

  2018-10-20

  

  Time-lapse images were taken on an inverted Zeiss LSM 510 microscope using Plan-Neofluar 20× (0.8 N.A.) objective. For Ca analysis, images were taken every 1.5s for 3min using 512×512 pixel resolution and cells were excited using the 488nm laser line. On each cell soma a 5μM×5μM ROI was drawn and ch

• CXCL has been previously identified as an estrogen regulated

  2018-10-20

  

  CXCL12 has been previously identified as an estrogen-regulated gene in estrogen receptor (ER)-positive ovarian and breast cancer adenosine antagonist (Jaerve et al., 2012). Here we show that in the endometrium, E2 significantly increased CXCL12 expression, suggesting a mechanism by which stem cells

• mek kinase The alternative corneal epithelial stem cell CESC

  2018-10-20

  

  The alternative corneal epithelial stem cell (CESC) hypothesis (Majo et al., 2008) accepts that LESCs exist but proposes that these are only used to repair wounds and that, during normal homeostasis, the corneal epithelium is maintained by stem cells, which are present throughout the corneal epithel

• br Materials and method br

  2018-10-20

  

  Materials and method Results Discussion Here we took advantage of a well-characterized model of skeletal muscle damage to study the effect of FAP ablation on skeletal muscle regeneration in vivo. Our results show that Nilotinib can effectively prevent transient ECM deposition following acut

• Previously we succeeded in visualizing the DNA

  2018-10-20

  

  Previously, we succeeded in visualizing the DNA methylation status by injecting a GFP-fused MBD of MBD1 protein (EGFP-MBD-NLS) mRNA into living mice zygotes. Using this method, we visualized the DNA methylation dynamics in preimplantation mouse embryos and found that DNA hypomethylation of major and

• In the adult mouse and

  2018-10-20

  

  In the adult mouse and human lungs, distinct region-specific epithelial progenitor cells have been described (Wansleeben et al., 2013), but their fetal counterparts remain undercharacterized. At E10.5–E12.5, Id2-expressing distal tip cells of the fetal lung buds are multipotent and contribute to the

• Experimental Procedures br Author Contributions

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in the coding region of the huntingtin (HTT) gene IT15 (MacDonald et al., 1993). The mutation produ

• Taken together we here show

  2018-10-20

  

  Taken together, we here show that the recently identified marker SPOT14 labels low-proliferating NSPCs in the hippocampus that react dynamically to positive and negative neurogenic stimuli in vivo. These data further validate the usefulness of this restrictive and functionally relevant marker to ana

• Direct cell reprogramming technology is

  2018-10-20

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

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