• Although GABA C receptors were originally described

  2022-02-12

  

  Although, GABA-C receptors were originally described in the spinal cord [16], clues to their physiological function arise mainly from studies in the visual system [5], [26]. In mammals, GABA-C receptors are found abundantly in cone photoreceptors and bipolar cell axon terminals, where they participa

• Recent evidence indicates that prolonged vasoconstriction

  2022-02-12

  

  Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs Merimepodib polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleation and el

• The presence of FBP in nuclei

  2022-02-11

  

  The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas

• br Author contributions br Declaration of conflict of intere

  2022-02-11

  

  Author contributions Declaration of conflict of interest Acknowledgements We are grateful to the Director, National Institute of Immunology for his support. The work was partially supported by J.C. Bose Fellowship to SSM. We acknowledge the help from staff of Small Animal Facility of Nation

• XCT790 The initial hyperproliferation phase during crypt

  2022-02-11

  

  The initial hyperproliferation phase during crypt regeneration is reminiscent of the effects of Apc loss during tumour initiation and genetic studies show Yap and Taz are also required for adenoma formation in mice [10••, 12•, 13]. Furthermore, Yap activation by Mst1/2 or Sav deletion increases cry

• br Experimental br Results br Discussion In

  2022-02-11

  

  Experimental Results Discussion In this study, we performed molecular docking analysis and in vitro studies to determine whether genistein binds to HIF-1α in BC CCT007093 and identify the residues involved in this interaction. We found that some functional groups (residues) mimic the bindi

• In order to better manage

  2022-02-11

  

  In order to better manage HBV infection and related liver diseases, it is critical to develop new antiviral strategies to increase the rate of functional or complete cure of HBV infection (HBsAg loss and cccDNA elimination), achieving more than viral suppression (Zeisel et al., 2015). As a result, m

• It has been reported that

  2022-02-11

  

  It has been reported that expression of murine haspin is found only in post-meiotic spermatids and that overexpression of murine haspin in HEK-293 cells leads to reduced cell proliferation. Therefore, it was suggested that haspin functions to bring about 3ct arrest in haploid germ cells (Tanaka et

• molecular calculator Polyunsaturated fatty acid components o

  2022-02-11

  

  Polyunsaturated fatty molecular calculator components of brain are more prone to oxidative attack, an event called lipid peroxidation. Consistent with previous findings on neurotoxicity [58,59], colistin sulphate increased the level of MDA in the brain of rats. The elevated MDA, a consequence of ov

• br Materials and methods br

  2022-02-11

  

  Materials and methods Results Discussion The compound P7C3 has been reported to activate NAMPT (Wang et al., 2014) and augment NAD+ levels, thereby promoting the survival of mature neurons and postnatal neurogenesis throughout the post-ischemic pi3k (Loris et al., 2017). However, it has bee

• Moreover there is a third possible GnRH

  2022-02-11

  

  Moreover, there is a third possible GnRH agonist target – the endometrium. The human endometrium has been shown to express high levels of both GnRH and GnRH receptors (Maggi et al., 2016), and GnRH agonists affect the function of the urokinase-type plasminogen activator/plasminogen activator inhibit

• br Materials animals and methods

  2022-02-11

  

  Materials, animals and methods Results Discussion This study presents mice with a missense point mutation in R258 of FFAR1 that has functional consequences. Firstly, in islets of Ffar1R258W/R258W mice, both the physiological agonist palmitate and the synthetic agonist TUG-469 were unable to

• Myosmine Although it is mainly a glial protein of

  2022-02-11

  

  Although it is mainly a glial protein, 5–10% of total GLT-1 represents a neuronal form located at presynaptic terminals, but its physiological role remains elusive (for discussion, see (Rimmele and Rosenberg, 2016)). Nevertheless, this amount might be significant since GLT-1 has been estimated to be

• Injury to oligodendrocyte progenitors caused in

  2022-02-11

  

  Injury to oligodendrocyte progenitors caused in part by glutamate contributes to the pathogenesis of myelination disturbances in PVL [5]. In the immature human brain, the susceptibility of developing oligodendrocytes to hypoxia-ischemia correlates with their expression of glutamate receptors of the

• Whether or not SMO and

  2022-02-11

  

  Whether or not SMO and SMO-dependent HH signaling play a role in hematopoiesis is a subject of strong controversy. Obviously, the effects of SMO deletion are highly contextual and dependent on the timing of deletion. transplanted murine Smo−/− fetal liver Schisandrol B receptor into sublethally irra

16311 records 511/1088 page Previous Next First page 上5页 511512513514515 下5页 Last page