• br Sources of chick stem cells br Applications and

  2018-11-08

  

  Sources of chick stem cells Applications and technologies related to chick stem cells Conclusions Conflict of interest Acknowledgments The authors\' work was supported by the Medical Research Council (MRC) and a Ph.D. scholarship from the programme “Strategic Scholarships for Frontier

• In the context of inflammation NF B p activation plays

  2018-11-08

  

  In the context of inflammation, NF-κB (p65) activation plays a central role in the regulation of pro-inflammatory cytokines (Klement et al., 1996). Elevated levels of TNF-α contributed to deficient healing as TNF-α upregulates its own synthesis and induces the production of IL-1β and IL-6 in fibrobl

• MicroRNAs miRNAs are small non coding

  2018-11-08

  

  MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. A recent study reported that ZEB1, another EMT activator, can directly suppress the transcription of miR-141, miR-200c, and miR-203 by interacting with their respective promoter regions. Mor

• Due to the limited proliferative capability of CMs large

  2018-11-08

  

  Due to the limited proliferative capability of CMs, large scale production of CMs is based on the expansion of pluripotent hESC followed by a CM differentiation step (Chen et al., 2014). Scaling up of hESC expansion in monolayer (MNL) culture platform is problematic mainly due to surface area limita

• We show that the PB

  2018-11-08

  

  We show that the PB transposon and its transposase are functional and quite efficient in terms of stable gene transfer to primary mesoangioblasts when compared to the transfection of plasmid vectors. Transposition occurred even when using large transposons comprising two expression cassettes and a s

• The following is the supplementary data related

  2018-11-08

  

  The following is the supplementary data related to this article. Author contribution Acknowledgments Introduction Endothelial progenitor b catenin inhibitor (EPCs) circulate in peripheral blood and migrate to a site for vascular formation and repair (Asahara et al., 1997). The pro-angiogen

• br Source of funding This work

  2018-11-08

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• br Resource table Resource details We reprogrammed

  2018-11-08

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• br Resource table br Resource details An induced

  2018-11-08

  

  Resource table Resource details An induced pluripotent stem cell (iPSC) line had been generated from human skin fibroblasts of a male, symptomatic 33-year-old spinocerebellar type 2 (SCA2) patient (anonymized as H271) using episomal vectors carrying transcripts for human OCT4, SOX2, KLF4, L-MY

• br Materials and methods br Acknowledgements We would like t

  2018-11-08

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• Our limited understanding of huSC biology can

  2018-11-08

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• To address this unmet need in

  2018-11-08

  

  To address this unmet need, in this work, we designed MBs targeting IRX4, a ventricular CM-specific transcription factor, generated homogeneous ventricular-like CMs from mESCs without altering their genome, and demonstrated that this method yielded functional ventricular CMs with high specificity an

• br Experimental Procedures br Author Contributions br

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments M. Ieda was supported by research grants from JST CREST, JSPS, Keio University Program for the Advancement of Next Generation Research Projects, Banyu Life Science, Senshin Medical Research Foundation, and Takeda Science Foundatio

• Specific histone modifications are currently used to define

  2018-11-08

  

  Specific histone modifications are currently used to define LCL161 regions with different regulatory functions. In particular, monomethylation of lysine 4 of histone 3 (H3K4me1) characterizes enhancer regions, whereas its trimethylation (H3K4me3) defines promoters (Ernst et al., 2011; Heintzman et 

• MiR p downregulated in OM MSCs has been

  2018-11-08

  

  MiR-140-5p (downregulated in OM-MSCs) has been reported to inhibit the expression of CXCL12 (Nicolas et al., 2008), which has been shown to promote oligodendroglial cell maturation in vitro (Göttle et al., 2010; Kadi et al., 2006) and myelination in the demyelinated cuprizone model (Patel et al., 20

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