• br Source of funding This work

  2018-11-08

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• br Resource table Resource details We reprogrammed

  2018-11-08

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• br Resource table br Resource details An induced

  2018-11-08

  

  Resource table Resource details An induced pluripotent stem cell (iPSC) line had been generated from human skin fibroblasts of a male, symptomatic 33-year-old spinocerebellar type 2 (SCA2) patient (anonymized as H271) using episomal vectors carrying transcripts for human OCT4, SOX2, KLF4, L-MY

• br Materials and methods br Acknowledgements We would like t

  2018-11-08

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• Our limited understanding of huSC biology can

  2018-11-08

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• To address this unmet need in

  2018-11-08

  

  To address this unmet need, in this work, we designed MBs targeting IRX4, a ventricular CM-specific transcription factor, generated homogeneous ventricular-like CMs from mESCs without altering their genome, and demonstrated that this method yielded functional ventricular CMs with high specificity an

• br Experimental Procedures br Author Contributions br

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments M. Ieda was supported by research grants from JST CREST, JSPS, Keio University Program for the Advancement of Next Generation Research Projects, Banyu Life Science, Senshin Medical Research Foundation, and Takeda Science Foundatio

• Specific histone modifications are currently used to define

  2018-11-08

  

  Specific histone modifications are currently used to define LCL161 regions with different regulatory functions. In particular, monomethylation of lysine 4 of histone 3 (H3K4me1) characterizes enhancer regions, whereas its trimethylation (H3K4me3) defines promoters (Ernst et al., 2011; Heintzman et 

• MiR p downregulated in OM MSCs has been

  2018-11-08

  

  MiR-140-5p (downregulated in OM-MSCs) has been reported to inhibit the expression of CXCL12 (Nicolas et al., 2008), which has been shown to promote oligodendroglial cell maturation in vitro (Göttle et al., 2010; Kadi et al., 2006) and myelination in the demyelinated cuprizone model (Patel et al., 20

• Pacemaking in SAN cells is a complex

  2018-11-08

  

  Pacemaking in SAN Romidepsin manufacturer is a complex process, explained by a combination of ion fluxes across the sarcolemmal membrane and the SR, designated as the calcium and membrane clocks (Lakatta et al., 2010). The mechanisms of spontaneous beating in hiPSC-CM are not well understood. Previ

• Among the epigenetic aberrations of iPSCs

  2018-11-08

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• This study is important as it tried

  2018-11-07

  

  This study is important as it tried to measure the sleep quality (through consecutive measurements) by simultaneously controlling the intervening variables (suffering from medical disorders, psychological disorders, abusing other substances, using psychotherapeutic medications, lapse and relapse) du

• monensin The level of tariffs TAR

  2018-11-07

  

  The level of tariffs TAR has the expected positive sign and statistical effects in all but specification 06. This result shows that the sectors with the highest degree of tariff protection are also given the additional protection of commercial defense, indicating an ability to lobby for more specifi

• br Methods A case report and pilot multicenter phase

  2018-11-07

  

  Methods A case report and pilot multicenter phase1–2 prospective interventional study (Mass. Eye and Ear, Boston, United States, and University of Crete, Heraklion, Greece) were conducted with institutional review board (IRB) approval, and informed consent was obtained from all participants. Sinc

• The progression of a GBM depends

  2018-11-07

  

  The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.

16276 records 1067/1086 page Previous Next First page 上5页 10661067106810691070 下5页 Last page