• Our limited understanding of huSC biology can

  2018-11-08

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• To address this unmet need in

  2018-11-08

  

  To address this unmet need, in this work, we designed MBs targeting IRX4, a ventricular CM-specific transcription factor, generated homogeneous ventricular-like CMs from mESCs without altering their genome, and demonstrated that this method yielded functional ventricular CMs with high specificity an

• br Experimental Procedures br Author Contributions br

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments M. Ieda was supported by research grants from JST CREST, JSPS, Keio University Program for the Advancement of Next Generation Research Projects, Banyu Life Science, Senshin Medical Research Foundation, and Takeda Science Foundatio

• Specific histone modifications are currently used to define

  2018-11-08

  

  Specific histone modifications are currently used to define LCL161 regions with different regulatory functions. In particular, monomethylation of lysine 4 of histone 3 (H3K4me1) characterizes enhancer regions, whereas its trimethylation (H3K4me3) defines promoters (Ernst et al., 2011; Heintzman et 

• MiR p downregulated in OM MSCs has been

  2018-11-08

  

  MiR-140-5p (downregulated in OM-MSCs) has been reported to inhibit the expression of CXCL12 (Nicolas et al., 2008), which has been shown to promote oligodendroglial cell maturation in vitro (Göttle et al., 2010; Kadi et al., 2006) and myelination in the demyelinated cuprizone model (Patel et al., 20

• Pacemaking in SAN cells is a complex

  2018-11-08

  

  Pacemaking in SAN Romidepsin manufacturer is a complex process, explained by a combination of ion fluxes across the sarcolemmal membrane and the SR, designated as the calcium and membrane clocks (Lakatta et al., 2010). The mechanisms of spontaneous beating in hiPSC-CM are not well understood. Previ

• Among the epigenetic aberrations of iPSCs

  2018-11-08

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• This study is important as it tried

  2018-11-07

  

  This study is important as it tried to measure the sleep quality (through consecutive measurements) by simultaneously controlling the intervening variables (suffering from medical disorders, psychological disorders, abusing other substances, using psychotherapeutic medications, lapse and relapse) du

• monensin The level of tariffs TAR

  2018-11-07

  

  The level of tariffs TAR has the expected positive sign and statistical effects in all but specification 06. This result shows that the sectors with the highest degree of tariff protection are also given the additional protection of commercial defense, indicating an ability to lobby for more specifi

• br Methods A case report and pilot multicenter phase

  2018-11-07

  

  Methods A case report and pilot multicenter phase1–2 prospective interventional study (Mass. Eye and Ear, Boston, United States, and University of Crete, Heraklion, Greece) were conducted with institutional review board (IRB) approval, and informed consent was obtained from all participants. Sinc

• The progression of a GBM depends

  2018-11-07

  

  The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.

• Breakpoint identification has been one of the most

  2018-11-07

  

  Breakpoint identification has been one of the most interesting fields in cytogenetics for investigating the phenotypic outcomes of reciprocal translocations. Several techniques had been developed to map chromosome breakpoints to the kilobase level (Chen et al., 2008; Gribble et al., 2009; Higgins et

• This study has several limitations First only papers publish

  2018-11-07

  

  This study has several limitations. First, only papers published in English were included. Publications in languages other than English were excluded due to insufficient information, which may lead to selection bias. Second, this study involved largely Asians and Caucasians; other ethnic subgroups (

• The clinical definition of frailty remains controversial but

  2018-11-07

  

  The clinical definition of frailty remains controversial, but one validated measure is the Frailty Index, where frailty is the result of an accumulation of health deficits over time, and the severity of frailty can predict adverse health outcomes (Rockwood and Mitnitski, 2007). In the general popul

• br MS data interpretation by database DB

  2018-11-07

  

  MS data interpretation by database (DB) searching ProteinLynx Global Server (PLGS) v2.5 (Waters) was used for peak picking and DB searching as described previously [3]. The searching DB contains 20,273 human protein entries extracted from UniProtKB/Swiss-Prot Release 2014_01. The DB searching res

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