• We used the response to

  2018-11-09

  

  We used the response to hepatitis B (HepB) vaccination as a model system to interrogate the global immunoglobulin heavy chain repertoire at multiple time points up to one month following booster vaccination with monovalent HepB surface antigen (HBsAg; Fig. 1). We show that the repertoire is variable

• br Introduction Diverse types of protease inhibitors PIs

  2018-11-08

  

  Introduction Diverse types of protease inhibitors (PIs) have been isolated, characterized, and evaluated for their biological potentials. They are small molecular mass peptides capable of inhibiting endogenous proteases. Plant PIs fascinates the attention of researchers because of their increasin

• The week in vitro culture

  2018-11-08

  

  The 15week in vitro culture protocol used in this study provided a very challenging culture system to examine long term potential of the cell sources. When grown in a large 6mm×9mm PCL scaffold, the AFS cathepsin inhibitor had great potential but the cells required an extensive induction time prior

• p-Cresyl sulfate manufacturer br Results br Discussion We tr

  2018-11-08

  

  Results Discussion We transiently coexpressed Er71, Gata2, and Scl during mesoderm formation stage in differentiating ESCs and greatly augmented hemangioblast generation, while near-completely blocking cardiac output. Similarly, we could convert hematopoietic field of the anterior lateral plat

• Why ectopic BRIGHT knockdown was capable of stimulating

  2018-11-08

  

  Why ectopic BRIGHT knockdown was capable of stimulating reprogramming by the conventional 4F method but not singularly is unclear. While BRIGHT levels in MEFs are modest compared to hematopoietic tissues (Webb et al., 2011), we were only able to achieve ∼75% reduction in transcript levels (Figure S1

• br Sources of chick stem cells br Applications and

  2018-11-08

  

  Sources of chick stem cells Applications and technologies related to chick stem cells Conclusions Conflict of interest Acknowledgments The authors\' work was supported by the Medical Research Council (MRC) and a Ph.D. scholarship from the programme “Strategic Scholarships for Frontier

• In the context of inflammation NF B p activation plays

  2018-11-08

  

  In the context of inflammation, NF-κB (p65) activation plays a central role in the regulation of pro-inflammatory cytokines (Klement et al., 1996). Elevated levels of TNF-α contributed to deficient healing as TNF-α upregulates its own synthesis and induces the production of IL-1β and IL-6 in fibrobl

• MicroRNAs miRNAs are small non coding

  2018-11-08

  

  MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. A recent study reported that ZEB1, another EMT activator, can directly suppress the transcription of miR-141, miR-200c, and miR-203 by interacting with their respective promoter regions. Mor

• Due to the limited proliferative capability of CMs large

  2018-11-08

  

  Due to the limited proliferative capability of CMs, large scale production of CMs is based on the expansion of pluripotent hESC followed by a CM differentiation step (Chen et al., 2014). Scaling up of hESC expansion in monolayer (MNL) culture platform is problematic mainly due to surface area limita

• We show that the PB

  2018-11-08

  

  We show that the PB transposon and its transposase are functional and quite efficient in terms of stable gene transfer to primary mesoangioblasts when compared to the transfection of plasmid vectors. Transposition occurred even when using large transposons comprising two expression cassettes and a s

• The following is the supplementary data related

  2018-11-08

  

  The following is the supplementary data related to this article. Author contribution Acknowledgments Introduction Endothelial progenitor b catenin inhibitor (EPCs) circulate in peripheral blood and migrate to a site for vascular formation and repair (Asahara et al., 1997). The pro-angiogen

• br Source of funding This work

  2018-11-08

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• br Resource table Resource details We reprogrammed

  2018-11-08

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• br Resource table br Resource details An induced

  2018-11-08

  

  Resource table Resource details An induced pluripotent stem cell (iPSC) line had been generated from human skin fibroblasts of a male, symptomatic 33-year-old spinocerebellar type 2 (SCA2) patient (anonymized as H271) using episomal vectors carrying transcripts for human OCT4, SOX2, KLF4, L-MY

• br Materials and methods br Acknowledgements We would like t

  2018-11-08

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

15582 records 1020/1039 page Previous Next First page 上5页 10161017101810191020 下5页 Last page