• br Specification of the mammalian germ cell lineage is an

  2018-11-09

  

  Specification of the mammalian germ cell lineage is an inductive process In model organisms such as Drosophila, C.elegans, Xenopus and Danio (zebrafish), PGCs are created each generation through a process known as pre-formation. This is a process driven by RNAs and proteins inherited from the ooc

• Previous studies including one in normal human

  2018-11-09

  

  Previous studies, including one in normal human fibroblasts, have demonstrated that HR activity is virtually absent during G1 phase, increases sharply in S phase, and begins to decrease by G2/M, whereas NHEJ activity occurs throughout the melatonin receptor agonist (Mao et al., 2008; Saleh-Gohari a

• Pluripotent ESCs and induced pluripotent stem

  2018-11-09

  

  Pluripotent ESCs and induced pluripotent stem Flavopiridol hydrochloride (iPSCs) represent a potentially unlimited source of skeletal cells for therapeutic applications. Several studies have established defined culture conditions to direct differentiation of mouse/human ESCs and human iPSCs into ch

• br Acknowledgments The study has been conducted with the

  2018-11-09

  

  Acknowledgments The study has been conducted with the financial support of the Russian Foundation for Basic Research (Grant no. 15-01-07923). Introduction Studying the scattering processes of charged and neutral particles of various natures is one of the most important problems in adenosine r

• kras-pdeδ inhibitor The second hypothesis relates to infants

  2018-11-09

  

  The second kras-pdeδ inhibitor relates to infants’ iron stores at birth, which form infants’ primary source of iron for the first months of life. Iron status of mothers during pregnancy is a key determinant of infant iron stores at birth (Allen, 2000). In our ENSIN sample we find that infants (6–12

• br Materials and methods br Results

  2018-11-09

  

  Materials and methods Results and discussion Conclusions The centre composite design of response surface methodology was successfully used in optimising the reaction conditions for biodiesel production from waste vegetable oil in the presence of csf-1r heterogeneous catalyst prepared from e

• Epigenetic age is comparable to chronological

  2018-11-09

  

  Epigenetic age is comparable to chronological age among cancer-free participants. Those with older epigenetic age relative to their chronological age have an elevated risk of cancer events within three to five years. Our study provides insight into using blood-based epigenetic age as a potential bio

• Our inhibitors act via an

  2018-11-09

  

  Our inhibitors act via an allosteric mechanism, i.e. they do not bind at the protein-protein interface. Such a mode of action has been seen with numerous small molecule inhibitors of enzymes, but there have only been limited reports of such allosteric inhibitors of protein-protein interactions (Arki

• Given the increasing intake of

  2018-11-09

  

  Given the increasing intake of high-fat and high-calorie diets in the post-industrialization era and the high prevalence of H. pylori infection at a global level, we therefore investigated the impact of H. pylori infection in combination with HFD on body insulin sensitivity and subsequent predisposi

• Given that ageing is the biggest risk factor for many

  2018-11-09

  

  Given that ageing is the biggest risk factor for many debilitating diseases that render individuals frail and rob them of their independence and dignity, there are strong moral and economic imperatives to tackle it and prevent the associated pathologies. Newly armed with an idea of how humans age, n

• In total the selected model explained se and

  2018-11-09

  

  In total, the selected model explained 60% (se=8%) and 98% (se=9%) of the phenotypic variation in MDD and SDD, respectively (Fig. 3). Strikingly, the effect of the shared couple environment contributed as much as 14% (se=7%) and 22% (se=7%) of the phenotypic variance in MDD and SDD respectively. For

• Memory reconsolidation may provide a basis from which

  2018-11-09

  

  Memory reconsolidation may provide a basis from which new therapeutic tools might be developed to improve clinical treatment of anxiety disorders in adolescents (Monfils et al., 2009; Schiller et al., 2010). These studies have shown that reactivating a conditioned stimulus opens a temporal window du

• In addition to these findings in adults there

  2018-11-09

  

  In addition to these findings in adults, there is emerging evidence from developmental fMRI studies demonstrating age-related hemispheric lateralization in the IPS. In a longitudinal fMRI study, Emerson and Cantlon (2014) recently demonstrated developmental differences in right and left IPS activati

• In order to analyze and illustrate

  2018-11-09

  

  In order to analyze and illustrate (Table 1, Figs. 2–3) steepness of changes in the EEG indexes during transitions from one stage to another, one-min values were further averaged on 3-min intervals (i.e., from minute −4 to −2, from −1 to +1, from +2 to +4, etc.). Additionally, all positive and negat

• In inverse problem solutions different

  2018-11-09

  

  In inverse problem solutions, different optimization techniques are used to estimate time dependent parameters, often related to root searching iterative methods belonging to the family of steepest descent and scaled steepest descent methods. Textbook [34] present general methods of solution of inve

15583 records 1019/1039 page Previous Next First page 上5页 10161017101810191020 下5页 Last page